Clinical Research of � endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis/This is only the Abstract link -- LDN(Low Dose Naltrexone) Forum

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Date Posted: 08:03:02 11/06/03 Thu
Author: Brenda
Author Host/IP: netcache-3001.bay.webtv.net / 209.240.205.60
Subject:

Clinical Research of � endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis/This is only the Abstract link

I am not a paying member of the Journal of Neurology Neurosurgery and Psychiatry.

JNNP -- Abstracts: Gironi et al. 74 (4): 495

http://jnnp.bmjjournals.com/cgi/content/abstract/74/4/495

� endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis

M Gironi1, R Furlan1, M Rovaris1, G Comi1, M Filippi1, A E Panerai2 and P Sacerdote2
1 Department of Neuroscience, San Raffaele Hospital, Milan, Italy
2 Department of Pharmacology, University of Milan, Milan, Italy

Correspondence to:
Dr M Gironi, San Raffaele, DIMER, Via Olgettina 48, 20132, Milan, Italy;
mgironi@dongnocchi.it

ABSTRACT

The possible link between the opioid peptide � endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of � endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest � endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest in patients with the progressive forms. Average � endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that � endorphin may have a role in the downregulation of the inflammatory process.

Keywords: � endorphin; multiple sclerosis; immunomodulation

Abbreviations: MS, multiple sclerosis; PBMC, peripheral blood mononuclear cells

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Re: LDN(Low Dose Naltrexone) upregulates the low � endorphin concentrations found in the blood of MS'ers (NT) -- Brenda, 08:33:17 11/06/03 Thu