RNA world -- Ben's Message Board

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Subject: RNA world

Author:
Wade A. Tisthammer
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Date Posted: 10/16/04 3:35pm
In reply to: Damoclese 's message, "RNA world" on 10/10/04 11:43am

>>
>>I don't remember if it was you or not but someone
>>directed me to a certain paper on RNA regarding the
>>alleged DNA-enzyme "chicken and the egg" type problem.
>
>I'm not sure what you mean here, but RNA doesn't
>require a DNA enzyme to replicate. It's
>self-replicating, leading to proteins and DNA later on.

Nonetheless I've also read that RNA probably suffers from some of the same sort of problems. For instance, while some RNA strings have catalytic properties (one of the reasons why DNA requires enzymes) the vast majority don't. High-fidelity replication is also a problem. Also the RNA-world hypothesis certainly it doesn't solve the problem of biological information necessary to code the relevant enzymes for DNA. So you still have the problematic jump to the DNA-enzyme relationship. In any case, the paper I looked up didn't address the problem it was allegedly supposed to.

Nonetheless, I concede that the RNA-world hypothesis has some merit even if it doesn't resolve the problem I was originally concerned with.

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Subject Author Date

RNA thoughts Damoclese 10/16/04 6:00pm

More thoughts. -- Wade A. Tisthammer, 10/31/04 1:53pm

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>>> >>>I don't remember if it was you or not but someone >>>directed me to a certain paper on RNA regarding the >>>alleged DNA-enzyme "chicken and the egg" type >problem. >> >>I'm not sure what you mean here, but RNA doesn't >>require a DNA enzyme to replicate. It's >>self-replicating, leading to proteins and DNA later >on. > >Nonetheless I've also read that RNA probably suffers >from some of the same sort of problems. For instance, >while some RNA strings have catalytic properties (one >of the reasons why DNA requires enzymes) the vast >majority don't. High-fidelity replication is also a >problem. Also the RNA-world hypothesis certainly it >doesn't solve the problem of biological information >necessary to code the relevant enzymes for DNA. So >you still have the problematic jump to the DNA-enzyme >relationship. In any case, the paper I looked up >didn't address the problem it was allegedly supposed >to. > >Nonetheless, I concede that the RNA-world hypothesis >has some merit even if it doesn't resolve the problem >I was originally concerned with.

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