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Date Posted: 11:05:03 03/03/04 Wed
Author: J.R.Smith, c.f.t. ISSA
Subject: Chromium Picolinate supplementation

Information on Chromium Picolinate

Research shows that chromium supplementation improves glucose tolerance in individuals with impaired glucose tolerance. Though the mechanisms remain unknown, chromium enhances cellular uptake of glucose possibly by facilitating binding of the large protein insulin to its receptor site within cells. Chromium also enhances the metabolism of carbohydrates, lipids, and amino acids. By increasing membrane fluidity, chromium may also increase cellular uptake of insulin and insulin efficiency. Decreased insulin sensitivity due to chronic chromium deficiency can, unfortunately, enhance the development of adult-onset type 2 diabetes. Chromium deficiency may increase craving for sweet foods and increase irritability (both associated with poor blood glucose control).

Chromium is part of the glucose tolerance factor or GTF. The complete identity of GTF remains unknown, but this hormone-like substance does contain chromium and niacin. With insulin, chromium in the form of GTF releases into the bloodstream when glucose (blood sugar) or insulin increases. With insulin, GTF promotes tissue uptake of fatty acids, amino acids, and sugars from the blood. Researchers believe GTF serves four other functions:

1. Helps to metabolize nutrients

2. Helps to create protein from amino acids

3. Helps to improve phagocytic (white blood cell) function

4. Helps to promote the use of glucose by the lens of the eye

Chromium helps to stimulate fatty acid synthesis and cholesterol in the liver. Consequently, supplementation with chromium in deficient individuals may improve their total blood lipid profile. Adding chromium to the diet raises high-density lipoprotein (HDL) and lowers low-density lipoprotein (LDL), thereby improving an individual’s coronary heart disease (CHD) risk based on the American Heart Association’s Cholesterol Risk Evaluation

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