VoyForums
[ Show ]
Support VoyForums
[ Shrink ]
VoyForums Announcement: Programming and providing support for this service has been a labor of love since 1997. We are one of the few services online who values our users' privacy, and have never sold your information. We have even fought hard to defend your privacy in legal cases; however, we've done it with almost no financial support -- paying out of pocket to continue providing the service. Due to the issues imposed on us by advertisers, we also stopped hosting most ads on the forums many years ago. We hope you appreciate our efforts.

Show your support by donating any amount. (Note: We are still technically a for-profit company, so your contribution is not tax-deductible.) PayPal Acct: Feedback:

Donate to VoyForums (PayPal):

Fri, November 22 2024, 9:18:24 PSTLogin ] [ Main index ] [ Post a new message ] [ Search | Check update time | Archives: 123456 ]
Subject: Relationship of HRQL to Treatment Adherence and SVR in CHC Patients


Author:
David Bernstein (HEPATOLOGY 2002;35:704-708.)
[ Next Thread | Previous Thread | Next Message | Previous Message ]
Date Posted: Sun, August 11 2002, 5:38:49 PDT
In reply to: H. Aaron Aronow,MD Neurology and Internal Medicine USC .. 's message, "Neurological manifestation of HCV" on Sat, May 19 2001, 10:27:06 PDT

Relationship of Health-Related Quality of Life to
Treatment Adherence and Sustained Response in Chronic
Hepatitis C Patients

David Bernstein,1 Leah Kleinman,2 Chris M. Barker,3 Dennis A. Revicki,2 and Jesse Green 4

Interferon therapy may exacerbate health-related quality of life (HRQL) deficits associated with hepatitis C virus (HCV) early in the course of therapy. Treatment with polyethylene glycol–modified interferon (peginterferon) alfa-2a (40 kd) provides improved sustained
response over interferon alfa-2a, but its effect on HRQL is unknown. The objective of this study was to (1) evaluate the effect of sustained virologic response on HRQL in patients with
HCV and (2) determine whether impairment of HRQLduring treatment contributes to early
treatment discontinuation.

Data consisted of a pooled secondary analysis of patients (n 51,441) across 3 international, multicenter, open-label, randomized studies that compared
peginterferon alfa-2a (40 kd) with interferon alfa-2a. ANCOVA was used to examine the
effect of sustained virologic response on HRQL. Repeated-measures mixed-models
ANCOVA was used to compare Fatigue Severity Scale (FSS) and SF-36 scores during treat-ment
by treatment group.

Logistic regression analysis was used to examine the association
between changes at baseline in on-treatment HRQL and early treatment discontinuation.


Sustained virologic response was associated with marked improvements from baseline to end
of follow-up in all subjects, including patients with cirrhosis. During treatment, patients
receiving peginterferon alfa-2a (40 kd) had statistically significantly better scores on both the
SF-36 and FSS. Baseline to 24-week changes in fatigue and SF-36 mental and physical
summary scores significantly predicted treatment discontinuation.

In conclusion, sustained
virologic response is associated with improvements in quality of life in patients with or
without advanced liver disease. This parameter may be an important consideration in max-imizing
treatment adherence. (HEPATOLOGY 2002;35:704-708.)

[ Next Thread | Previous Thread | Next Message | Previous Message ]

Replies:
Subject Author Date
Central nervous system involvement in patients with hepatitis C infectionRev Neurol (Paris) 2002 Dec;158(12):1202-4Thu, January 02 2003, 19:20:55 PST


Post a message:
This forum requires an account to post.
[ Create Account ]
[ Login ]

Forum timezone: GMT-8
VF Version: 3.00b, ConfDB:
Before posting please read our privacy policy.
VoyForums(tm) is a Free Service from Voyager Info-Systems.
Copyright © 1998-2019 Voyager Info-Systems. All Rights Reserved.