Author:
De Martino L,et al; Muscle Nerve 2003 Jan;27(1):102-4
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Date Posted: Fri, January 03 2003, 16:24:18 PST
In reply to:
H. Aaron Aronow,MD Neurology and Internal Medicine USC ..
's message, "Neurological manifestation of HCV" on Sat, May 19 2001, 10:27:06 PDT
Muscle Nerve 2003 Jan;27(1):102-4
Viral RNA in nerve tissues
of patients with hepatitis C infection and peripheral neuropathy.
De Martino L, Sampaolo S, Tucci C, Ambrosone L, Budillon A, Migliaresi S, Di Iorio G.
Department of Neurological Sciences, Second University of Naples, 80131 Naples, Italy.
To assess the presence of viral ribonucleic acid (RNA) in nerve tissues of 15 patients with hepatitis C virus (HCV) infection and peripheral neuropathy with (11) or without (4) mixed cryoglobulinemia, nested reverse transcription-polymerase chain reaction (RT-PCR) was performed. Amplification of HCV-RNA was successful in 7 patients with and 3 without mixed cryoglobulinemia.
This study demonstrates that the nested RT-PCR technique is a sensitive method to detect viral RNA in nerve tissue, and offers further evidence that in patients with HCV infection peripheral neuropathy can occur in the absence of mixed cryoglobulinemia.
Muscle Nerve 27:102-104, 2003
PMID: 12508302 [PubMed - in process]
Hepatitis C Outreach Project
www.hcop.org
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