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Subject: Association between hepatitis C virus core protein and carotid atherosclerosis Author: Ishizaka Y, et al: Circ J 2003 Jan;67(1):26-30 [ Next Thread | Previous Thread | Next Message | Previous Message ] Date Posted: Sun, January 12 2003, 9:30:22 PST In reply to: H. Aaron Aronow,MD Neurology and Internal Medicine USC .. 's message, "Neurological manifestation of HCV" on Sat, May 19 2001, 10:27:06 PDT Circ J 2003 Jan;67(1):26-30   Association between hepatitis C virus core protein and carotid atherosclerosis. Ishizaka Y, Ishizaka N, Takahashi E, Unuma T, Tooda E, Hashimoto H, Nagai R, Yamakado M. Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital. A link between certain infectious microorganisms and an increased risk of atherosclerotic disease has been suggested. By analyzing the data of subjects who had undergone general health-screening tests, a possible association between carotid atherosclerosis and seropositivity of antibody against hepatitis C virus (HCV) has been previously reported. In the present study, a possible link between carotid atherosclerosis and HCV core protein positivity was assessed, because it is postulated to be a better marker of viremia and thus persistent infection. Of the 1992 enrolled subjects, 496 (25%) had carotid artery plaque, and 25 (1.3%) were positive for HCV core protein. Carotid artery plaque was positive in 480/1967 (24%) and 16/25 (64%) of the core protein-negative and core protein-positive subjects, respectively (p<0.0001 by chi(2) test). Serum concentrations of transaminases were higher in core protein-positive subjects, but albumin concentrations were not significantly different between the 2 groups. Multivariate logistic regression analysis showed that HCV core protein positivity is an independent predictor of carotid plaque with an odds ratio of 5.61 (95% confidence interval 2.06-15.26, p<0.001). These data further support the possible link between persistent HCV infection and carotid atherosclerosis in the subjects without severe liver dysfunction. PMID: 12520147 Source: Hepatitis C Outreach Project (www.hcop.org) [ Next Thread | Previous Thread | Next Message | Previous Message ]

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Subject Author Date Defective memory function in early hepatic encephalopathy Weissenborn K, et al; Journal of Hepatology 2003; 39(3): 320-5 (September 2003) Fri, August 15 2003, 10:41:34 PDT